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Skeletal research in an adult rat model reported increased periosteal bone formation when the secretagogue was studied alongside glucocorticoid exposure [5]
ASL is funded by the National Institutes of Health grant 5T32DK007135-46
These insights have driven the development of synthetic GLP-1R/GCGR co-agonists aimed at achieving long-term metabolic benefits
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In animal studies, GLP1-agonists were associated with reduced fetal weight and/or growth, delayed ossification and skeletal variants, usually associated with a reduction in maternal weight gain and decreased food consumption
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