As Blyumin put it, they were given limited use authorizations to compound these drugs that otherwise they shouldnt be able to, because theyre on patent. Now, those shortages have ended, and compounding pharmacies no longer have a legal basis for producing identical copies of GLP-1s
References Adams JD, Chang ML, Klaidman L: Parkinson's disease--redox mechanisms
Non-CG methylation in the human genome
If you experience severe vomiting or diarrhea during dose escalations, the mechanical absorption of oral medications may be compromised
Studies on other peptides of similar size suggest that enzymatic degradation can reduce bioavailability by 50-80% even before accounting for barrier permeability limitations
Modern formulations and dosing strategies have improved safety, and current guidelines emphasize individualized decision-making rather than generalized avoidance