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The anti-metabolite drug MTX is frequently used to treat cancer and inhibit the immune system

The primary transport protein for L-leucine, L-type amino acid transporter (LAT), shows heightened expression in stimulated keratinocytes and immune cells including T cells, B cells, T cells, macrophages, and NK cells

This helps the mitochondria (the powerhouses of the cell) to produce cell energy effectively and the cells to maintain a healthy metabolism

280 , H23212328 (2001)

[25] It is important to note that because glutathione synthetase deficiency is so rare, it is poorly understood