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Fe 3+ absorbed into the cell is located in the endosomes and is reduced to ferrous iron (Fe 2+ ) by transmembrane epidermal antigen of prostate 3 (STEAP3) [70]

Transepidermal water loss is increased, and the barrier ability to keep irritants and pathogens out is reduced

Too little peptide and gene expression changes remain subtle

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Recent studies demonstrate the potential of inducing ferroptosis in HSCs using magnesium isoglycyrrhizinate, artesunate, or artemether as a therapeutic strategy designed to mitigate the development of liver fibrosis [82, 83]

The ROS generation was detected with a Leica fluorescence microscope (Leica DM6000B) using Leica LAS X software, and quantitative analysis was performed with ImageJ software (version 1.60