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MDHAR has not been reported in the lumen of chloroplast (Obara et al., 2 in absence of MDHA (Miyake et al., AsA-GSH pathway in mitochondria The presence and activity of AsA-GSH cycle enzymes in mitochondria of plant cells have been established, and this cycle plays an important role in protecting mitochondrion against the toxic ROS regularly produced in respiratory chain reactions (Leonardis et al., 2 -fixing legume root nodules (Iturbe-Ormaetxe et al., P

10.1210/endo-127-5-2217 45 LeiS.ClydesdaleL.DaiA.CaiX.FengY.YangD.et al (2018)

These disorders are associated with a range of symptoms, including anorexia, weight loss, impaired neural function, mental problems, muscle weakness and heart enlargement

Systemic corticosteroids (prednisone) may be used for more extensive disease, though they are not appropriate for maintenance due to significant adverse effects with prolonged use