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Finally, in the fourth subgroup (ALC combination vs placebo), GI events were most frequent in both arms, followed by CNS
Sonthalia S, Daulatabad D, Sarkar R
By applying a reverse translational approach that evaluates compounds with emerging clinical efficacy, we demonstrated that semaglutide, tirzepatide, and retatrutide blunt alcohol interoceptive/subjective effects, potentially clarifying a clinically meaningful mechanism
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This evolution in treatment highlights an urgent need for evidence that moves beyond weight loss alone to examine long-term cardiometabolic health, quality of life, and durability of treatment effects. Concerns about youth on GLP-1 According to Messiah, GLP-1 medications have demonstrated meaningful benefits for adolescents living with obesity, including substantial weight reduction and improvements in obesity-related conditions such as type 2 diabetes and hypertension, but she underscores that drugs need to be prescribed appropriately and accompanied by ongoing medical supervision
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