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Its approved to treat major depressive disorder, seasonal affective disorder, and smoking cessation under the brand name Zyban

Demand exceeded supply for the first several months after launch, leading to periodic shortages

Gastrointestinal symptoms in particular are directly related to the GLP-1-mediated slowing of gastric emptying that also produces appetite suppression

An interruption of just six months before resuming treatment still reduced the cardiovascular benefit, leading to a 4% to 8% increased risk compared to continuous use

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