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Long-term data on semaglutide now extends beyond five years for diabetes indications and approximately three years for weight management, with ongoing extension studies continuing to accumulate evidence

CKD patients may experience slightly higher rates of nausea initially due to reduced GI motility and slower gastric emptying

They help regulate blood sugar, slow digestion, and reduce cravings, making it easier to stick to a healthy eating plan

Crucial NITs in NAFLD patients stratification are especially the fibrosis-4 (FIB-4) - an index that takes into account age, transaminases and platelet count- and the liver stiffness evaluation by VCTE

The isoforms are divided into three types: short (LepRa, c, d, and f), long (LepRb), and secreted (LepRe) forms [16] (Fig