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A top pQTL is the top (most significantly associated) variant per megabase bin

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You should contact your healthcare provider if: Persistent, severe hunger continues despite being on the 2.4 mg maintenance dose for at least 812 weeks, particularly if accompanied by inadequate weight loss (less than 5% of initial body weight) Sudden increase in appetite after previously experiencing good appetite control, which may indicate treatment tolerance or an underlying medical issue Symptoms suggesting hypoglycaemia (shakiness, sweating, confusion, intense hunger) occur, especially if you have type 2 diabetes or are taking other glucose-lowering medications

Androgen-dependent prostate cancer cells reprogram their metabolic signature upon GLUT1 upregulation by manganese superoxide dismutase

[1] [4] For patients with diabetes, additional monitoring for diabetic retinopathy is recommended, and those on insulin or sulfonylureas may require dose adjustments to prevent hypoglycaemia

As of early 2026, the most recent GLP-1 approvals include the Wegovy pill (oral semaglutide 25mg, approved December 2025) and Wegovy HD (semaglutide 7.2mg injection, approved March 2026)