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In mammalian nervous systems, many different types of chemical substances, including amino acids (e.g., glutamate), monoamines (e.g., dopamine, norepinephrine), acetylcholine, peptides (e.g., substance P), serve as neurotransmitters to bind their corresponding receptors, then activate ion channels, and consequently produce ion flux 1 , thereby inducing membrane potential changes that lead to signal propagation for neurotransmission 1,2,3,4

These medications appear to affect brain pathways involved in reward and craving, which could help explain the lower rates of substance use disorders observed in our study. The researchers said the findings do not establish cause and effect and cautioned against prescribing the medications for addiction treatment without further study

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