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In one landmark trial, adults without diabetes who took the highest weekly dose lost an average of 20.9 percent of their body weight over 72 weeks, compared with 3.1 percent on placebo, and more than half reached at least a 20 percent reduction (SURMOUNT-1 trial, New England Journal of Medicine, 2022)

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Slower Metabolism Hashimotos disease often leads to hypothyroidism, which can reduce the number of calories your body burns at rest