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Oral progesterone in HRT serves a critical safety function: it protects the uterine lining (endometrium) from the effects of unopposed estrogen, which can lead to endometrial hyperplasia and potentially cancer

Because arm subcutaneous tissue tends to be thinner, there is a slightly higher risk of accidentally injecting too shallowly (into the dermis) or too deeply (into the muscle)

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doi: 10.1590/s1516-31802012000300009

The broader semaglutide UTI analysis reaches the same reassuring conclusions

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