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GLP-1 medications slow stomach emptying, leading to a steadier rise in blood sugar after meals

If your iron, zinc, vitamin D, or protein levels were already borderline before starting retatrutide, the additional metabolic stress of rapid weight loss will push them over the threshold faster

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This effect is mediated through central melanocortin signaling pathways, the same system that becomes dysregulated in genetic obesity syndromes involving MC4R mutations

The choice of therapy depends on multiple factors, including medical history, side effect profile, convenience, cost, and personal preferences