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SGLT2is as Foundational Therapy in Adults with CKD There was a clear consensus that SGLT2is should be positioned as foundational therapy in adults with CKD and T2D, independent of BMI and in particular in the presence of HF, given their consistent kidney protective benefits and well-established mechanisms of action [20,21,22]

Clarke, S

Some researchers report usable potency beyond 28 days, but the safety margin narrows significantly after that point