glp 1 postmenopausal women on the GLP-1 medication tirzepatide (Zepbound) for obesity lost more weight if they were also using menopause hormone therapy, a retrospective cohort study indicated. https://www.medpagetoday.com/endocrinology/menopause/119594 Women's Hormonal Health and Longevity:

Although preclinical data generally suggest a positive impact of adiponectin on bone homeostasis through the reduction in osteoclast activity and the increase in osteoblastic differentiation, clinical studies present conflicting results

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