Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2
Targeted plasma metabolomic analysis For the plasma metabolomic analysis, a 12-h fasted venous blood sample (20 mL) was collected into EDTA-coated vacutainer tubes and centrifuged (Hettich Rotina 46R5) for 15 min at 2,500 RPM at 4 C
Elevated levels of MTA and SAMe are tightly linked to T-cell exhaustion in hepatocellular carcinoma (HCC), and deletion of a key SAMe-producing enzyme MAT2A results in inhibition of T-cell exhaustion and limitation of HCC growth in mice (86)
Additionally, mice that were intermittently fed showed increased running endurance
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