Tirzepatides dual mechanism distinguishes it from earlier GLP-1 therapies
At 50% uptake, and assuming a 15.5% discontinuation rate as observed in the SOUL trial, an estimated 59,332 MACE, 14,215 cardiovascular deaths, 41,744 nonfatal myocardial infarctions, and 12,260 nonfatal strokes could be prevented
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The reviewer YP declared a shared parent affiliation with the author YS to the handling editor at the time of the review
One prime example is the discovery of the nutrient sensing mechanism for cholesterol, which led to the development of life-saving statin drugs (and the Nobel Prize)
How retatrutide works: the triple mechanism Understanding retatrutide's three-pronged approach explains both its impressive efficacy and its potential