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ABHD5/CGI-58, the ChanarinDorfman syndrome protein, mobilises lipid stores for hepatitis C virus production
One possible explanation is that low serum vitamin B12 levels would trap folate as 5-methyltetrahydrofolate, prevent the generation of methionine from homocysteine, and therefore reduce protein synthesis and lean tissue deposition
It also enhances ease of administration and maintains patient comfort
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For patients requiring additional therapeutic effect, the dose may be increased to 1 mg of semaglutide weekly after at least four weeks at the 0.5 mg dose
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