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Even when these medications are used in appropriate clinical circumstances, it is important to have a multifaceted lifestyle plan in place when weaning off these medications
Other mechanisms underlying the effects of GLP-1 RAs on exercise capacity include improvements in myocardial energetics, enhanced endothelial function, reductions in systemic inflammation and oxidative stress and modulation of skeletal muscle metabolism
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In the pivotal phase II clinical trial of retatrutide in obesity, published in the New England Journal of Medicine in 2023 (Jastreboff et al
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Cancer Detect Prev , 31:499-540
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