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It does not interact with P-glycoprotein (ABCB1) efflux transporters based on its peptide structure and rapid degradation profile [3]
The lyophilized powder is generally stored cold and protected from prolonged light and heat, since the coordinated copper can participate in oxidation reactions that alter the complex over time
superoxide anion (O2), singlet oxygen radical (1O2), peroxyl radical (ROO), nitric oxide radical (NO) and lipid peroxy radical (LOO) as well as peroxynitrate (ONOO), trichloromethane (CHCl3) and hypochlorous acid (HOCl) which are not necessarily free radicals but have high tendency to generate free radicals
The results of these studies support and confirm observations in-vivo indicating that intact DSIP crosses the BBB by simple transmembrane diffusion
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The molecule also binds platinum-based chemotherapy drugs with hepatocyte-like cells to form a complex that leads to apoptosis or cell death by necrosis
