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However, gastrointestinal adverse effects may lead to dehydration and acute kidney injury, particularly in patients with pre-existing renal disease, so close monitoring is advised

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This effect is particularly beneficial for patients with diabetes or obesity, who often have elevated triglyceride and VLDL levels

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Frontiers in Endocrinology , 14, Article 1067551

Emerging evidence suggests that treatment with the dual GLP-1 and GIP receptor agonist, tirzepatide, might prove even more potent than a GLP-1RA alone, to ameliorate NAFLD