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Gastrointestinal adverse events - predominantly nausea, vomiting, diarrhea, and constipation - are the most common class effects, occurring in 20%-60% of patients depending on the agent and dose, and are typically of mild-to-moderate severity, dose-dependent, and most prominent during titration

Commonly associated with the GHK-Cu component due to its vascular effects

Providers typically prescribe a low starting dose and gradually increase it based on your response and tolerance for side effects

Some people, on the other hand, may pull hair from their eyelashes, beards, or eyebrows

What Happens at Steady State: Plateau Dynamics and Extended Dosing One of the most clinically significant findings from the 12mg retatrutide dosage cohort was the absence of a weight loss plateau at 48 weeks

Understanding why requires a closer look at how these molecules function inside the body