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In preclinical studies, systemic administration of GLP-1 receptor agonists has been shown to reduce cocaine-induced CPP ( In vivo microdialysis studies have shown that GLP-1 receptor activation reduces dopamine release in reward-related regions such as NAc, indicating a suppression of dopaminergic reinforcement mechanisms ( The doses used in some of these studies also produced non-specific behavioral effects, such as reduced locomotor activity or induced malaise ( Regarding the lack of liraglutide effect in the extended-access study, this model precipitates neuroplastic changes in dopamine and glutamate signaling within reward circuits, which may reduce the sensitivity to GLP-1 receptor agonist intervention ( Another key issue in this line of research is the pharmacokinetic properties of LIR in rats, including absolute bioavailability and brain penetration, as well as typical side effects of the GLP-1 receptor agonist class, such as nausea
* Lopez P, et al
Neuropharmacology 67 , 326330 (2013)
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276 Pathological prion instigates neuronal death, which in turn causes secondary astrocytic reactivity predominantly in the white matter, but the roles of reactive astroglia in prion diseases are poorly understood and hampered by the emerging complexity of astrocyte responses to prion induced pathologies
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