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The STEP-1 trial demonstrated mean weight loss of 14.9% with semaglutide over 68 weeks, while the SURMOUNT-1 trial showed tirzepatide achieving 16-22.5% weight reduction over 72 weeks
While the underlying metabolic dysfunction persists and would likely return if medication stopped, the daily reality for these individuals resembles non-diabetic glucose metabolism
Statistically, these alterations were different compared to the placebo group
Retatrutide is a new hope in this area
Mistake 2: Shaking the vial to dissolve Vigorous shaking creates shearing forces between liquid layers that can damage peptide bonds
These fractional draws are trickier and benefit from a syringe with half-unit markings
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