insulin levels, C-peptide, glucagon, GLP-1 and GIP (total and intact) were also measured
In addition, they may have other modes of action, as causing oxidative stress, genetic susceptibility, and epigenetic modifications (e.g., DNA methylation, miRNA) (17, 62, 63), ultimately resulting in gene expression changes (62, 64, 65) in particular when exposure occurs during prenatal and early postnatal life
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These results demonstrated that tirzepatide 10 and 15 mg had the lowest NNT, where an additional patient achieving the 5% weight reduction threshold would be observed if treating an additional 1.47 and 1.46 patients with tirzepatide 10 and 15 mg, respectively, rather than placebo