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Whether GLP-1/GIP drugs can impact fibrosis remains an open basic and clinical question

Researchers have also noted that 70% of diabetes patients discontinue GLP-1 receptor agonist treatment within two years, limiting the long-term efficacy of these drugs

Moreover, several clinical studies show that glycemia improves when doses are increased but with unacceptable rates of gastrointestinal adverse events 16,17,18 , suggesting that maximum benefits from GLP-1R agonism are in fact not realized with current treatments

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73 Telomeres are responsible for maintaining DNA integrity