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Due to the high expression profile of GLP-1R in pancreatic -cells, GLP-1 analogs (such as exendin-4) have been modified by different methods (to prolong half-life, maintain receptor binding affinity and reduce renal drug accumulation) for theranostic purposes and serve as excellent templates for future cardiovascular drug development[178-184]

Plasma was collected post-euthanasia, stored at 80C, and analysed for insulin and GCG levels by ELISA

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Achieving these targets significantly reduces the risk of long-term diabetes complications