It it, it affects the liver's function and it affects cardio metabolic disease
The discomfort associated with cold injections may be related to the temperature difference between the cold solution and body tissue
In developmental toxicity studies, tirzepatide administration during organogenesis resulted in decreased fetal growth and increased incidences of skeletal malformations in both rats and rabbits
While not a listed adverse reaction in the SmPC, persistent forceful vomiting can theoretically lead to Mallory-Weiss tearssmall lacerations in the oesophageal mucosa that may bleed
Several sex effects were also observed throughout these studies, where despite higher levels of total plasma acylcarnitines in females compared to males, in aging females, there was a significant decrease in total acylcarnitines which was not seen in aging males, indicating that aging may impact female peripheral lipid bioenergetics more than males
Studies to clarify the riskbenefit ratio of DKA and improved cardio-renal outcomes with SGLT2i use in type 1 diabetes are required to help inform future guidelines and standardise clinical practice
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