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They dont address whats happening at the tissue level the cellular damage, the inflammation that wont shut off, the collagen that stopped rebuilding, the nerve signals that keep firing after the original injury is long gone
The standard dosage range of 50-150 mg daily for oral administration aligns with calculated human equivalent doses from animal research
A quick primer on the molecules behind one of dermatology's most-studied bio-actives
These include the POMC-derived peptides released by neighbouring keratinocytes and the neuropeptide calcitonin gene-related peptide, substance P, and neuropeptide Y released from intramucosal free nerve endings, which are in close contact with melanocytes in the basal cell layer of the epithelium
Abalos, F
Statements Author contributions LC contributed in collecting bibliography, in writing the manuscript, and in conceiving and creating the figures
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