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As a result, the PPAR system can potentially treat atherogenic dyslipidemias

Elevated fatty acids (FAs) activate Toll-like receptors (TLRs) in macrophages, which act in synergy with MSU crystals to trigger NLRP3 inflammasome activation and pro-inflammatory cytokine release (e.g., IL-1), thereby initiating the inflammatory cascade

10.3389/fphys.2021.745296 Front Physiol

If the FDA eventually adds one or more of these substances to the 503A Bulks List, qualifying pharmacies could potentially use them in patient-specific compounded medications when the remaining requirements of Section 503A are met

10.1128/MCB.06743-11 90 KleinbongardP.SchulzR.RassafT.LauerT.DejamA.JaxT.et al