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Alternatives the physician considered, including the option of no treatment

In accordance with another embodiment, a method for increasing circulating and/or intracellular levels of glutathione comprises orally administering to an individual in need thereof a delayed-release, gastro-resistant capsule which contains an amount of S-acetyl-glutathione (SAG) effective to increasing circulating and/or intracellular levels of glutathione

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However, they still require close monitoring, especially regarding blood sugar levels

Patient-related factors: These remain unchanged from the original categorization

In addition, the high penetration level through the stratum corneum alone can be explained by the fact that there was no tissue retention from underlying skin that may have limited penetration