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Diabetes Obes Metab (2019) 21(1):1208

A: Melanosis coli is a dark brown-black discoloration of the colonic mucosa most often seen with exposure to anthraquinone laxatives (Figure 1)

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Rare Risks: Though uncommon, serious complications such as gallbladder issues or pancreatitis can occur

And the storyinteresting here, people think about the long-acting as convenience, but actually the long-acting gave us a flatter, steadier drug profile so that the side effects were less bothersome