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Quick Answer: Metformin and semaglutide combined produce additive A1C reductions of roughly 1.5 to 2.5% Stacked, you get a broader attack on hyperglycemia: less glucose released from the liver, more insulin secreted in response to meals, less appetite, and slower nutrient absorption
Efficacy was maintained at week 48
It is also one of the most frustrating aspects of practicing obesity medicine
Most patients describe the injection as a "quick pinch" with minimal pain during insertion
Weight typically drops after menstruation begins
And for many, thats the missing piece
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