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5-Amino-1MQ targets the substrate binding site of NNMT the nicotinamide binding pocket competitively inhibiting nicotinamide methylation with an IC50 of 1.2 M under reference assay conditions

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Yet, mitochondria function is also essential for neuronal processes involving Ca 2+ fluxes and homeostasis, which play important roles on the stability of action potentials in the plasmatic membrane of these organelles, promotion of protein folding through chaperones and axonal transport and synapse processes, among others (Knott et al., 2008)