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The combination did not show any apparent deleterious effect in wild type controls (Fig
Studies on athletes show whole-body cryotherapy reduces circulating levels of the pro-inflammatory cytokine IL-1 beta while increasing the anti-inflammatory cytokine IL-10 and the cytokine inhibitor IL-1 receptor antagonist (IL-1ra)
REFERENCES 1Brackett CC, Singh H, Block JH
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MOTS-c activates AMPK (AMP-activated protein kinase), the master metabolic switch that signals cells to increase glucose uptake, accelerate fat oxidation, and promote mitochondrial biogenesis
