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NPs-induced downregulation of endothelial nitric oxide synthase (eNOS) expression, causing impaired endothelium-dependent vasorelaxation and promoting reactive oxygen species creation in endothelial cells, which was associated with high NADPH oxidase expression, with subsequent downregulation of Sirt1 expression [76]
Nevertheless, it is clear that the uptake of glutamate and the synthesis of GSH must be maintained at high levels for cancer development
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Oral and topical treatment of painful diabetic polyneuropathy: practice guideline update summary: Report of the AAN guideline subcommittee