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Enhanced Glutathione: NAC (a precursor to glutathione) can boost the levels of glutathione in your body, enhancing its effectiveness in detoxifying and brightening your skin

Glutathione tackles this at a biological level by: Inhibiting tyrosinase activity to slow down melanin production Shifting melanogenesis from eumelanin (darker) to pheomelanin (lighter) Acting as an antioxidant to reduce the oxidative stress that triggers hyperpigmentation A 2025 systematic review in the International Journal of Dermatology confirms that oral glutathione at doses of 250 mg twice daily and 500 mg once daily showed a significant reduction in melanin index compared to placebo, particularly in sun-exposed areas like the face and wrists

Anti-psychotic medication and some contraceptive formulations have been used in this way