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John DiBella Published: June 18, 2024 Fact-checked by Dr

COX-2 selective NSAIDs (i.e., COX-2 inhibitors or coxibs) inhibit COX-2 more strongly than COX-1, resulting in less gastrointestinal side effects, but potential cardiovascular complications, most notably an increase in the risk of heart attack due to increased blood clotting propensity (see below) (Conaghan 2012)

When to seek medical attention: Severe or persistent abdominal pain (stop medication and seek urgent carepotential pancreatitis) Persistent nausea or vomiting affecting hydration or nutrition Signs of gallbladder disease (right upper quadrant pain) Symptoms of hypoglycaemia if taking other diabetes medications No weight loss after 3 months at maintenance dose Regular monitoring, including weight, waist circumference, blood pressure, and metabolic parameters, should be conducted throughout treatment to assess efficacy and safety

Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates

This state leads to the blockage of ATP dependent potassium channels and the subsequent membrane depolarization, followed by the secretion of the hormonal cargo

coli under anaerobic conditions to enable intracellular compound activation