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Wilfley DE, Crow SJ, Hudson JI, Mitchell JE, Berkowitz RI, Blakesley V, Walsh BT, Sibutramine Binge Eating Disorder Research Group

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Side effects included nausea (39% of patients), diarrhea (25%) and vomiting (28%) [29] Overall, orfoglipron achieves comparable weight loss with other GLP1R agonists such as semaglutide and Rybelsus, but has a slightly better side effect profile and achieves weight loss in a shorter period of time

Because of the technical difficulties in investigating the microglia function directly, Wang et al