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The cumulative load is called oxidative stress

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A systematic review found 48.4% to 70.6% of perimenopausal women report hot flashes or night sweats

Their antioxidative properties stem from neutralizing ROS via direct radical scavenging or by enhancing endogenous antioxidant defense mechanisms, such as the Nrf2 pathway, reducing oxidative cellular damage 189

& LeBoit, P

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