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JACC 82(9):833955 Rangaswami J, Bhalla V, de Boer IH, Staruschenko A, Sharp JA, Singh RR et al (2020) Cardiorenal protection with the newer antidiabetic agents in patients with diabetes and chronic kidney disease: a scientific statement from the American Heart Association

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do not shake vigorously Inspect solution Should be clear and colorless Label vial Date, concentration, batch number Refrigerate Store at 2-8C immediately Calculating Doses For research applications, accurate dose calculation is critical: Example Calculation: Cagrilintide 10mg vial Reconstituted with 2mL bacteriostatic water Concentration: 10mg 2mL = 5mg/mL For 0.6mg dose: 0.6mg 5mg/mL = 0.12mL (12 units on insulin syringe) For 1.2mg dose: 1.2mg 5mg/mL = 0.24mL (24 units on insulin syringe) For 2.4mg dose: 2.4mg 5mg/mL = 0.48mL (48 units on insulin syringe) Detailed guidance on peptide preparation and dosing can help ensure accurate research protocols

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