STEP UP Phase 3 Trial Design The sNDA incorporates data from the STEP UP trial (NCT05646706), a 72-week, randomized, double-blind, placebo- and active-controlled superiority study involving 1,407 adults with obesity (BMI 30 kg/m)
GLP-1 analogues have shown promise in improving cardiovascular health by reducing the risk of heart disease in individuals with obesity and diabetes
Both of these subsets need a ton more data such as patients who stopped using CPAP machines due to sleep apnea resolution, change in amount of daily pain medication taken in the arthritis basket, etc
The mechanism of action, whereby GLP-1 agonists mimic the natural hormone to regulate appetite (Nauck and Meier, 2016)
Since managing type 2 diabetes involves ongoing in-person testing and physical exams that can't be fully conducted via telehealth, Klinic does not prescribe Ozempic
One key difference between liraglutide and tirzepatide is how often you take the medications