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The obtained areas under the total concentrationtime curve for drug in the brain and plasma (AUC total ) are used for calculation of K p,brain or can be combined with unbound fraction determined by equilibrium dialysis to calculate K p,uu,brain using a combinatory mapping approach (87, 97)
doi: 10.3389/fphar.2024.1337282 Received 12 November 2023 Accepted 18 March 2024 Published 02 April 2024 Volume 15 - 2024 Edited by Jia-You Fang, Chang Gung University, Taiwan Reviewed by Sergio Alberto Bernal Chvez, Universidad de las Amricas Puebla, Mexico Zhixing Wu, University of Florida, United States Andr Rolim Baby, University of So Paulo, Brazil Updates Copyright 2024 Ghasemiyeh, Fazlinejad, Kiafar, Rasekh, Mokhtarzadegan and Mohammadi-Samani
So knowing what's in the bloodstream is only indicating how much B12 has not been absorbed or used by the body yet
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