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Manifestations and etiologies of vitamin B12 deficiency in adults Vitamin B12 deficiency is relatively frequent in elderly patients, around 2 to more than 30% according to depending on the target population, the design and location of the studies, but is often unrecognized or not investigated because the clinical manifestations of vitamin B12 deficiency are subtle [5]

Researchers often study it in lab work on Nicotinamide N-Methyltransferase (NNMT)

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Metformin, commonly prescribed for diabetes, and proton pump inhibitors used for acid reflux can both reduce B12 absorption over time

It can serve not only as a core tool for metabolic research, but also play a role in the study of more metabolismrelated diseases including polycystic ovary syndrome and metabolic syndrome, while helping to further elucidate NNMTrelated energy metabolism mechanisms