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However, it should be emphasized that use of caloric restriction to control for weight-dependent effects in DIO mouse studies may potentially introduce confounding effects on microbiome signatures due to significant compensatory changes in hunger sensation, feeding pattern, resting metabolic rate and gut morphology which may be disproportionately to that attained by appetite suppressants 80,81

Carnitine transport in human intestinal biopsy specimens: demonstration of an active transport system

In contrast, blood glucose level of 54 mg/dL or less occurred in 6% of patients receiving the 14 mg tablets, 3% of patients receiving placebo, and 0% of patients receiving the 7 mg tablets

doi:10.1016/j.molmet.2019.09.010 Elliott RM, Morgan LM, Tredger JA, Deacon S, Wright J, Marks V

Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1 in mice

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