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Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum KA, et al

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We also believe that their overuse and abuse are inevitable

Indeed, numerous studies have revealed significant cellular changes in age-associated delayed healing: altered haemostasis [138, 139], reduced re-epithelialisation [140, 141], an excessive inflammatory response [142, 143] and upregulated protease activity associated with reduced matrix deposition [144]

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