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Simple measurements like waist circumference and mid-arm circumference, tracked over time, also give useful information about fat and muscle trends

When HbA 1c was measured in %, tirzepatide at doses of 15 mg, 10 mg and 5 mg demonstrated greater efficacy than semaglutide at doses of 2.0 mg (MD = 0.38% [95% CI 0.75% to 0.01%]), 1.0 mg (MD = 0.45% [95% CI 0.60% to 0.31%]) and 0.5 mg (MD = 0.51% [95% CI 0.68% to 0.33%]), respectively (ESM Table 7)

Discordance usually came from differing step therapy protocols (e.g

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It has well-established anti-inflammatory and free radical-scavenging effects and may slow the effects of aging on blood vessels

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