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Gradual Dose Escalation Gradual dose escalation proceeds with: Weeks 1-4: 1 mg once daily Weeks 5-8: 2 mg once daily Thereafter: Adjustment based on individual response and goals Dosing Frequency Options Dosing frequency most commonly involves once daily administration (morning or evening), with alternative protocols using 2-3 times per week at 2 mg per injection

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Barrett et al., Obesity Treatment With Bariatric Surgery vs GLP-1 Receptor Agonists, JAMA Surgery, published online Sept

Metab Syndr Relat Disord (2011) 9:314

IGF-1 is a small peptide that circulates in plasma with the majority (98%) bound to the IGF-binding proteins (IGFBP)

She explains that, beyond a certain dosage, increasing the amount of the drug no longer enhances its analgesic effects