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Whether glucagon counter-regulation to hypoglycemia is affected during DPP-4 inhibition in type 2 diabetes has been studied in drug-nave subjects (138), in subjects when a DPP-4 inhibition was added on to insulin therapy (139), and in elderly subjects with metformin-treated type 2 diabetes (140)
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In rats, reduced growth and fetal abnormalities (visceral and skeletal) were observed at clinically relevant exposures at the maximum recommended human exposure (MRHD)
