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In fact, the hypothalamus, mesolimbic area and prefrontal cortex, three areas involved in executive functioning, are directly involved in controlling energy balance

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Higuchi N, Kato M, Shundo Y, Tajiri H, Tanaka M, Yamashita N, Kohjima M, Kotoh K, Nakamuta M, Takayanagi R, Enjoji M (2008) Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease

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Clinical trials show its most common side effects are gastrointestinal: nausea affects up to 85% of patients, diarrhea occurs in about 23%, and constipation and abdominal discomfort are also frequently reported